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Project Partners

Prof. Dr. Jürgen Kurths

Institute of Physics / Nonlinear Dynamics
University Potsdam
Am Neuen Palais 10, Building 19
14469 Potsdam
Germany
Tel. (+49) 331 977 – 1611
Fax (+49) 331 977 – 1142
jkurths@agnld.uni-potsdam.de

Core Competency:

The AG Nonlinear Dynamics has a strong background in the investigation of complex biological systems. Areas of expertise include simulation and analysis of complex dynamical systems, nonlinear data and time series analysis, properties of complex biological networks, theory and application of synchronization and noise-induced phenomena. Ongoing projects include mathematical and in silico models for the regulation of metabolism (protein synthesis, degradation), effects of noise in models of cellular regulation, investigation of gene expression, identification of dynamical regimes in synthetic genetic oscillators, modelling of bone reformation and cognitive mechanisms.

Contribution to Work Programme:

WP1: Development of mathematical models and simulation methods, close collaboration with JGR1 in the development of mathematical descriptions of metabolic processes (WP 1.4, WP4), models to support the analysis of protein turnover (WP2), nonlinear data analysis and reconstruction of models from data (WP1.1, WP1.3), analysis of transient responses with respect to environmental stimuli (WP3.3), analysis of fundamental design principles of gene, protein and metabolite networks (WP1.3, WP4.2), investigation of dynamical regimes in models of circadian regulation (WP1.4, WP4). The major contribution of this partner will be to WP1.

GoFORSYS Publications of the Group:

Arenas, A., A. Diaz-Guilera, et al. (2008). "Synchronization in complex networks." Physics Reports - Review Section of Physics Letters 469(3): 93-153.

Ullner, E., A. Koseska, et al. (2008). Dynamics of multicelluar synthetic gene networks. Handbook on Biological Networks, World Scientific Publishin.

Ullner, E., J. A.Koseska, et al (2008), „The multi-stability of synthetic genetic networks with repressive cell-to-cell communication.“ Physical review E 78(3 Pt 1): 031904.

Zamora-Lopez, G., V. Zlatic, C.Zhou, et al.(2008). „Reciprocity of networks with degree correlations and arbitrary degree sequences“, Physical Review E. 77(1):8, 016106;

Koseska, A., E.Volkov, J.Kurths, (2009) „Detuning-dependent dominance of oscillation death in globally coupled synthetic genetic oscillators“, Europhysics Letter 85(2).

Koseska, A., A. Zaikin, et al. (2009). "Timing cellular decision making under noise via cell-cell communication." PLoS ONE 4(3): e4872.