|
|
Project PartnersDr. Dirk Walther
Core Competency:Computational biology and bioinformatics; complex data analysis with focus on gene expression data, genomic sequence information, gene ontologies and protein structure; machine learning techniques for marker identification and sample classification. Contribution to Work Programme:WP1: Development of databases for the integration of the various heterogeneous datasets using concepts developed under the Resource Description Framework (RDF); graphical visualization method and bioinformatics analysis tool development; cross-species comparisons Chlamydomonas / other model organisms / higher plants and eukaryotes based on sequence, gene ontology, protein structure and abundance information; correlation network analyses from profiling experiments. The major contribution of this partner will be to WP1. GoFORSYS Publications of the Group:May, P., S. Wienkoop, et al. (2008). "Metabolomics- and proteomics-assisted genome annotation and analysis of the draft metabolic network of Chlamydomonas reinhardtii." Genetics 179(1): 157-166. Nikoloski, Z., S. Grimbs, et al. (2008). "Metabolic networks are NP-hard to reconstruct." Journal of Theoretical Biology 254(4): 807-816. Childs, L., Z. Nikoloski, et al. (2009). "Identification and classification of ncRNA molecules using graph properties." Nucleic Acids Research. Christian, N., P. May, et al. (2009). "An integrative approach towards completing genome-scale metabolic networks." Molecular Systems Biology. Gunther, S., J. von Eichborn, et al. (2009). "JAIL: a structure-based interface library for macromolecules." Nucleic Acids Research 37: D338-D341. Kempa, S., D. Walther, et al. (2009). Metabolic Engineering. Molecular Biology and Biotechnology. J. M. Walker and R. Rapley, Royal Society of Chemistry. May, P., J. O. Christian, et al. (2009). "ChlamyCyc: an integrative systems biology database and web-portal for Chlamydomonas reinhardtii." BMC Genomics 10(1): 209. |
|
Group Leader Bioinformatics
Contact
