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Project PartnersDr. Zoran Nikoloski (former Dr. Ebenhoeh)University of Potsdam, Institute of Biochemistry and Biology/Genetics Core Competency: Within GoFORSYS, JRG1 is involved in three work packages: (1) WP1 (General bioinformatics and computational methods), with particular contribution to WP1.3 (Integrated data analysis) and WP1.4 (Modeling and simulation methods), (2) WP3 (Multilevel systems analysis of responses in C. reinhardtii), specifically WP3.1 (Different steady state conditions) and WP3.3 (Time resolution of responses in transients), and (3) WP4 (Testing and applicability of models), with contributions to WP4.2 (Similarity of regulatory networks).The research objectives of JRG1 within GoFORSYS include: (1) Development of in silico models of metabolic and regulatory networks related to photosynthetic activity and carbon metabolism in C. reinhardtii coupled with transfer/adaptation of these models to higher model plants (e.g., A. thaliana), (2) Integration of quantitative experimental data to discriminate, validate, and further refine the resulting mathematical descriptions, (3) Integration of qualitative network-based models to achieve comprehensive descriptions of the system, involving multiple interacting hierarchies of levels (i.e., transcripts, polysomes, proteins, metabolites) and characterization of the global network properties based on their predictive power, and (4) Theoretical approaches to the analysis of metabolic fluxes as a determinant of network functionality.Former Project leader: Dr. Oliver Ebenhoeh Institute for Complex Systems and Mathematical Biology ebenhoeh@abdn.ac.uk |
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